Autoimmune liver diseases (ALD) occur when the immune system turns against liver cells, leading to inflammation. Types of ALD include autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The detection of specific disease-associated antibodies allows for a differential diagnosis of the culprit ALD, and helps to ensure proper patient treatment. Here we discuss the specific autoantibodies associated with either AIH, PBC, or PSC, as well as the techniques available for their detection.
Dr. Ruth Brignall completed a PhD in immunology and a post-doc in cancer biology. She joined Oxford Immunotec, first as a Medical Science Liaison (MSL) and more recently as a Global Medical Expert. Below, we will learn more about her experiences and insights in tuberculosis and SARS-CoV-2 diagnostics.