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Allergy testing identifies common allergens including foods and inhalation that are often harmless but may cause allergies in some patients. There are two main allergy testing methods, skin-prick and blood tests, that can assess the presence of allergen-specific IgE antibodies. Combining an IgE-antibody blood test result with case history and a physical examination has clear clinical advantages when making a diagnosis.

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Autoimmune liver diseases (ALD) occur when the immune system turns against liver cells, leading to inflammation. Types of ALD include autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC). The detection of specific disease-associated antibodies allows for a differential diagnosis of the culprit ALD, and helps to ensure proper patient treatment. Here we discuss the specific autoantibodies associated with either AIH, PBC, or PSC, as well as the techniques available for their detection.

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As the Delta variant spreads across the world, many vaccinated individuals are worried about the possibility of a breakthrough infection. The term “breakthrough infection” refers to the development of a COVID-19 infection despite an individual being vaccinated against the virus. With many Americans still reluctant to vaccination, and with mask mandates lifted in most states, the highly contagious Delta virus has contributed to spikes in COVID-19 cases across the nation this summer ’21.

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KOL Spotlight Interviews is a segment where we interview experts in various fields on their expertise and insights that continue to help shape the diagnostics and pharmaceutical industries. This month, we have the pleasure of welcoming Dr. Animesh Sinha, a renowned dermatologist from University at Buffalo. Below, we will learn more about diagnostic methods for autoimmune bullous dermatoses conditions.

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Dermatophyte infections are difficult to diagnose clinically as they can resemble other skin disorders. Without proper diagnosis and treatment, dermatophyte infections can lead to permanent damage of the hair, skin, and nails. Molecular diagnostic testing of fungal infections allows for the accurate detection of dermatophytes that might be difficult to grow in culture, or in cases where a dermatophyte infection has already been treated, and allows for species-specific identification.

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Meet Lisa Ann, a patient who was diagnosed with a rare autoimmune skin blistering disease after many misdiagnoses. She shares her story from the first symptoms and frustrations, testing and multiple doctor visits, and how she lives and manages this condition today. Check out this Patient Journey to hear from Lisa Ann and learn what diagnostic tests are available for these rare skin diseases.

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Invasive Aspergillosis (IA) is an infection caused by Aspergillus. People with weakened immune systems or lung diseases are at a higher risk of developing IA. It is one of the most commonly under-detected diagnoses in ICU patients. Because symptoms are not specific, it is important to know which diagnostic tests can aid in early detection and management of IA.

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Less than a year after the World Health Organization (WHO) declared COVID-19 a global pandemic, the authorization of several novel COVID-19 vaccines has created hope for a healthier future. Recent studies have demonstrated that both humoral and cellular immunity play a role in protection from COVID-19. Additionally, the development of novel COVID-19 vaccines requires a look at the immune response in order to determine the effectiveness of the vaccine at preventing infection.

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There is a need for continuous monitoring of therapeutic levels of TNF-α inhibitors to promote individualized treatment while affirming that patients receive the most accurate and cost-effective regimen available. With the MabTrack ELISA, clinicians can make effective adjustments based on semi-quantitative results and can facilitate simplified decision-making with their patients for improved long-term response.